A First in Man Study of MABp1 in Patients With Advanced Cancers

Inclusion Criteria: * pathologically confirmed advanced malignancy that is metastatic or unresectable and which is refractory to standard therapy or for which thee is no standard therapy that provides benefits for \>/= 3 months * measurable or non-measurable disease at baseline * at least 4 weeks since the last dose of chemotherapy, radiation therapy, immunotherapy, or surgery; at least 6 weeks for therapy which is known to have delayed toxicity; at least 4 weeks since treatment with biologic/targeted therapies; at least 2 weeks since last hormonal therapy * will not be treated with any other chemotherapy, immunotherapy, radiotherapy or investigational drug while enrolled on this protocol * age \>/= 18 year, male or female * Eastern Cooperative Oncology Group performance status 0,1,or 2 * Serum potassium and magnesium levels within institutional normal limits. Total serum calcium or ionized calcium level must be greater than or equal to the low limit of normal. * Adequate renal function, defined by serum creating \</= 1.5 x ULN * Adequate hepatic function * Adequate bone marrow function WOCBP, a negative serum pregnancy test result at screening. * WOCBP or men whose sexual partners are WOCBP who are willing to use an acceptable method of contraception for at least 1 month prior to study entry, for the duration of the study, and for at least 3 months after the last dose of study medication * Signed and dated IRB approved ICF before any protocol specific screening procedures are performed Exclusion Criteria: * serious uncontrolled medical disorder or active infection which would impair the patient to receive protocol therapy. * Uncontrolled or significant cardiovascular diseae * dementia or altered mental status that would prohibit the understanding or rendering of informed consent * not recovered from the adverse effects of prior therapy at the time of enrollment \</= grade 1 * symptomatic brain metastases which are either untreated or uncontrolled by surgery and or radiotherapy * received extensive prior radiation therapy to the bone marrow * immunocompromised, including subjects know to be infected with HIV * history of hypersensitivity to compounds of similar chemical or biologic composition to the antibody women how are pregnant or breastfeeding * WOCBP or men whose sexual partners are WOCBP who are unwilling or unable to use an acceptable method of contraception for at least 1 month prior to study entry, for the duration of the study, and for at least 3 months after the last dose of study medication