The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients. For this purpose, the investigators enrolled bone marrow transplant recipients and observed the developement of tuberculosis after the transplantation.
All adult bone marrow transplant recipients admitted to Asan Medical Center will be enrolled. Quantiferon-Gold In-Tube assay will be performed. Isoniazid prophylaxis will be given only to patients with clinical risk factors (i.e. recent contact with active pulmonary TB patient or inadequate treatment history with abnormal CXR). However, isoniazid prophylaxis will be not given based on positive TST or positive Quantiferon-Gold In-Tube assay.
Study Type
OBSERVATIONAL
Enrollment
409
Asan Medical Center
Seoul, South Korea
development of tuberculosis
Time frame: after transplantation
all cause mortality
Time frame: after transplantation
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