Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery

Yonsei University48 enrolled

Overview

The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Enrollment

Conditions

Coronary Artery Occlusion

Interventions

N-acetylcysteine, salineDRUG

Inject 100 mg/kg of N-acetylcysteine or the equivalent amount of saline for 15 minutes before the skin incision, then continuously inject 40 mg/kg/day of N-acetylcysteine or the equivalent amount of saline during the next 24 hours.

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients with Euroscore ≥ 5 Exclusion Criteria: * Patients in need of emergency surgery,acute renal failure patients, kidney transplanted patients, patients injected with NAC 5days before planned surgery

Locations (1)

Severance Hospital

Seoul, South Korea

Data from ClinicalTrials.gov

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