Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell

Phase 1TerminatedNCT01021176

Pennington Biomedical Research Center12 enrolled

Overview

The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.

You will fast on your first visit. Complete questionnaire about taste and smell to insure you don't have a cold or anything that would interfere with sense of smell. Your nose will be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or a placebo. Your sense of smell will be tested at different time points.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Food Intake

Interventions

Placebo sprayOTHER

0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray yet no drug will be administered

DiltiazemDRUG

0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray Three Dilutions would be 5.5, 6.0 and 6.3 and the fourth at the filp of a coin randomly diluted.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index (BMI) between 25 and 40 kg * Blood pressure in within normal range Exclusion Criteria: * Used tobacco products in the past month * Used a calcium channel blocker medication in the last month * used nasal sprays in the last month * have an abnormal sense of smell or abnormalities of the lining in your nose * female and have irregular menstrual periods * female and are nursing a baby or pregnant * female and have had a partial hysterectomy (still have ovaries)

Locations (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Outcomes

Primary Outcomes

Evidence of blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray.

Time frame: 3 weeks

Data from ClinicalTrials.gov

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