Study to Assess Safety, Tolerability and Pharmacokinetics After Single and Multiple Doses of AZD1446 to Japanese Subject

Inclusion Criteria: * Healthy Japanese subjects, aged ≥20 to ≤50 years for male young subjects, ≥65 to ≤80 years for male or post-menopausal female elderly subjects. * BMI between 18 and 27 kg/m2 and weigh at least 50 kg and no more than 90 kg (for the elderly female, weigh at least 45 kg and no more than 90 kg). Exclusion Criteria: * History of Quincke oedema or angiooedema, or history of repeated episodes of urticaria. * History or present symptoms or signs of asthma, airway hyperreactivity or obstructive lung disease.