Identification of Stroke Patients ≤ 3 and ≤ 4.5 Hours of Symptom Onset by Fluid Attenuated Inversion Recovery (FLAIR) Imaging and Diffusion Weighted Imaging (DWI)

Götz Thomalla, MD643 enrolled

Overview

The aim of the study is to evaluate the use of combined fluid attenuated inversion recovery (FLAIR) imaging and diffusion weighted imaging (DWI) as surrogate marker of lesion age within the first 6 hours of ischemic stroke in order to identify patients ≤ 3 or ≤ 4.5 hours of symptom onset in a large multicenter study hours of ischemic stroke. The investigators hypothesize that the pattern of a visible lesion on DWI together with a negative FLAIR ("DWI-FLAIR mismatch") will identify patients ≤ 3 hours of symptom onset with \>80% specificity and positive predictive value.

Study Type

OBSERVATIONAL

Enrollment

643

Conditions

Acute Ischemic Stroke

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute ischemic stroke (proven by initial or follow-up MRI) * Well defined and known symptom onset * Stroke MRI including diffusion weighted imaging (DWI) and fluid attenuated inversion recovery (FLAIR) sequences performed within 12 hours of symptom onset * Informed consent Exclusion Criteria: * Contraindications against MRI

Locations (2)

Charite Clinical Center

Berlin, Germany

Outcomes

Primary Outcomes

Specificity (and 95% CI) of "DWI-FLAIR-mismatch" for the identification of patients ≤3 and ≤4.5 hours

Time frame: on admission

Secondary Outcomes

Predictors of a "negative FLAIR" in acute ischemic stroke

Time frame: on admission