Rosuvastatin for Preventing Deep Vein Thrombosis

Hallym University Medical Center180 enrolled

Overview

Deep vein thrombosis (DVT)is devastating disease which influencing the mortality and morbidity of patients at-risk like those undergoing orthopedic surgery. Recent publication suggested HMO-co-A reductase inhibitor (statin) may reduce the occurrence rate of venous thromboembolism in apparently healthy persons. The pleiotropic property of statin like antioxidant, antithrombotic, anti-inflammatory may have effect on the positive results. We are investigating whether rosuvastatin is associated with lower incidence of deep vein thrombosis (DVT) in patients undergoing total knee replacement arthroplasty(TKRA)who are at-high risk for developing DVT

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

180

Conditions

Deep Vein Thrombosis Venous Thrombosis Prevention

Rosuvastatin 20mg/d for 14daysDRUG

Rosuvastatin 20mg/day for 7days before and 7days after index surgery (total knee replacement arthroplasty, TKRA) Enoxaparin 40mg SQ/day 12hr before TKRA and from 1day to 7day after TKRA should be administered at the same time with rosuvastatin.

enoxaparin onlyDRUG

enoxaparin 40mg sq/day only starting 12hr before TKRA and from on day 1 to 7 after index surgery

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are going to receive total knee replacement arthroplasty from any cause. * \< 19 years old Exclusion Criteria: * patients with cancer * Patients receiving anticoagulant agents from any cause * current statin users * expecting survival from other co-morbidity \< 1year * Bed ridden patient * AST, ALT \> 3times of upper normal limit * CK\> upper normal limit * pregnancy * patients who receives hormone replacement therapy

Outcomes

Primary Outcomes

Development of deep vein thrombosis diagnosed and confirmed by CT angiography at lower extremities

Time frame: 7days after index surgery

Secondary Outcomes

D-dimer, lipid panel (Total cholesterol, TG, HDL, LDL), hsCRP, CK, transaminase, ALP

Time frame: 7days, 1month, 2month after index surgery