Evaluation of Objective Perimetry Using Pupillometer

N/ACompletedNCT01021982

Sheba Medical Center60 enrolled

Overview

Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in areas of visual field defects in RP and Glaucoma patients.

Pupil light reflex will be measured by a pupillometer in response to short and long wavelength light small spot stimulus in different area of the visual field. The PRL will be measured in four quadrant, central, 10, 20, and 30 degree from the visual axis. Stimulus duration will be 1000 ms (1 sec), with intervals of 890 ms between stimuli. The stimuli size V with light intensity of 39.8 cd-s/m2 for both short wavelength stimuli (peak 485 nm) and long wavelength stimuli (peak 620nm).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Retinitis Pigmentosa Glaucoma Visual Field

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-75 2. Sign on informed consent 3. Papillary response to light. 4. Groups of : Normal , Glaucoma patients with early glaucoma damage on HVF (nasal step ect. ), Glaucoma patients with advanced glaucoma damage on HVF (arcuate , tubular vision ) and RP patients (Early VF damage , ring scotoma ) . 5. Refractive correction up to -3.5 D. Exclusion Criteria: 1. Cloudy corneas. 2. Surgical intraocular ophthalmic procedure within the past 30 days. 3. Nonreactive pupils. 4. Synechia of the iris to the lens after surgery or inflammation . 5. Neovascularization. 6. Iris coloboma. 7. Sphincter damage due to ischemia or trauma (tears of sphincter or diffuse damage to muscle). 8. Sphincter damage due to high intraocular pressure . 9. Iris tumor or cyst . 10. Ectropion uvea . 11. Adie's pupil . 12. Optic neuropathy with the potential for producing a positive RAPD (Relative Afferent Pupillary Defect ). 13. Chronic use of myotics or mydriatics. 14. Systemic Medication which affect on papillary response . 15. Any condition preventing accurate measurement or examination of the pupils.

Locations (1)

Sheba Medical Center

Tel Litwinsky, Israel, Israel

Outcomes

Primary Outcomes

PLR response amplitude and latency

Time frame: Not defined yet

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.