To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.
* Validate the clinical use of a mircofluidic device to capture circulating timor cells from a broad range of tumor types * Characterize and identify these circulating tumor cells and demostrate cell viability with this capture method * Apply this technology in clinically relevant settings and correlate to response to treatment and disease progression * Elucidate predictive and pharmacodynamic biomarkers in the context of early phase trials of novel therapeutics
Study Type
OBSERVATIONAL
Enrollment
817
National Cancer Centre
Singapore, Singapore
RECRUITINGThe validation of the clinical use of a microfluidic device to capture circulating tumor cells (CTC) from a broad range of tumor types
Time frame: 3 years
Characteristics and viability of the CTC with this capture method
Time frame: 3 years
Clinical application of this capture method with the study of CTC titre correlation to treatment outcome
Time frame: 6 years
Study of predictive and pharmacodynamic biomarkers of the CTC in the context of early phase trials of novel therapeutics
Time frame: 6 years
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