The Preemptive Analgetic Potency of Low Dose S-Ketamine

Medical University of Graz60 enrolled

Overview

The primary hypothesis is improved postoperative analgetic quality using S-Ketamine, particularly in patients suffering from chronic pain.

The investigators are dealing mainly with the finding of the right dosage for the optimal safety and efficacy of S-Ketamine, but also discovering new possible areas of investigation (e.g. anti-depressive effect, anti-neuropathic effect).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Pain

Interventions

S-KetamineDRUG

drug

Placebo ComparisonOTHER

saline control

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled for major abdominal surgery * Suitable for PCA * Cardio-vascular stable * Age: 18+ * Between 50-120kg BW * ASA 1-3 * Good Compliance for pain monitoring Exclusion Criteria: * Allergy to S-Ketamine * Severe liver or kidney dysfunction * Severe coronary disease * Pregnancy * Present or past psychotic disorders * Addiction to alcohol or opioids * Poor compliance

Locations (3)

Medical University Graz

Graz, Styria, Austria

Medical University of Graz

Graz, Styria, Austria

Medical University of Graz

Graz, Austria

Outcomes

Primary Outcomes

postoperative opioid consumption

Time frame: 1 year

Data from ClinicalTrials.gov

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