Evaluation of the Irinotecan/Bevacizumab Association for Naive Unresectable Glioblastoma

Inclusion Criteria: All the eligibility criteria must be met before registration : * delay upper or equal to 14 days from stereotaxic biopsy and 28 days from surgical biopsy * Histopathologically proven diagnosis of glioblastoma (WHO grade IV astrocytoma) * Patient belonging to the RPA V class or associated * only supratentorial glioblastoma * Diagnosis must be obtained by a stereotactic or surgical biopsy * Age between 18 and 70 * A contrast-enhanced MRI must be performed within 28 days prior to study registration * Total or partial surgical resection deemed as not possible by a neurosurgeon * Karnofsky Index (KI) performance status over 50 * Life expectancy of at least 3 months * A stable dose of corticosteroid for at least 7 days to control intracranial pressure and neurological symptoms * Adequate blood function : absolute neutrophil count \> 1.5 x 109/L, platelets count \> 100 x 109/L platelets; hemoglobin \> 10 g/dl after blood transfusion if required * Adequate liver function: bilirubin \< 1.5 ULN (upper limit of normal), ALT and AST \< 2.5 ULN, Prothrombin rate \> 75 % * Adequate renal function: creatinine \< 1.2 ULN; proteinuria test 0 or trace (or urine protein concentration \< 1g/24h if proteinuria test is + or ++). * Negative pregnancy test for women of childbearing potential and adequate contraception for men and women. * systolic arterial blood pressure at rest ≤ 170 mmHg * Patient must have been informed and must have signed the specific informed consent form. * holder of a coverage by the health insurance Exclusion Criteria: * patient belonging to the RPA III or IV * prior malignant tumor in the recent 5 years or concomitant malignancy * prior anti-tumoral chemotherapy or radiotherapy * prior gross resection of the brain tumor * patient receiving gliadel * cardiovascular contra-indications to bevacizumab : prior angina pectoris, prior myocardial infarction, prior brain stroke, even transient, distal severe arteriopathy, uncontrolled high blood pressure * anticomitial drug p450 cytochrome inductors * other substances inducing p450 cytochrome * proteinuria ≥ 1g/L * concurrent anticoagulant or platelet anti-aggregant treatment * congenital haemorrhagic pathology (haemophilia, Willebrandt) * sign of brain haemorrhage on the RMI initial exam * non resolved infectious disease * non controlled arterial hypertension (≥170 mmHg) * intracranial high pressure not controlled by a stable dose of steroids for at least 7 days * pregnancy or refusal of the contraception for women and men * psychiatric, behavioural disorders or geographical situation precluding the administration or follow-up of the protocol (including claustrophobia) * digestive haemorrhage and / or gastro-duodenal ulcer occurring in the last 3 months * pregnant, nursing woman, or without contraception * private individuals of freedom or under tutelage (including legal guardianship)