The purpose of this study is to investigate the safety and efficacy of Levosimendan given preoperative to patients with heart failure undergoing noncardiac surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
At least 2 hours before surgery: Infusion of Levosimendan (0,1 microgram/kg/min.). 24 hours of infusion without a bolus.
ml/kg/hours - same infusion rate as active comparator
Oslo University Hospital - Ullevål
Oslo, Norway
Vestfold Hospital Trust
Tønsberg, Norway
Mölndal Hospital
Gothenburg, Sweden
Universitety Hospital Örebro
Hudiksvall, Sweden
Heartfailure - Highest NT-proBNP-value the first 7 days after surgery
Time frame: NT-proBNP 6 hours postoperative, 24 hours postoperative, 48 h postoperative, 72 h postoperative, 96 h postoperative, 120 h postoperative, 144 h postoperative and 168 h postoperative
Days of hospitalization
Time frame: Hospital stay - number of days patients are hospitalized
Use of inotropes (dopamine, Norepinephrine)during postoperative unit stay. Mg/microgram
Time frame: After 16-18 hours, after 48 hours and every 24 hours if still in the PO-Unit
Mortality
Visits or patients record
Time frame: 30 days
Ischemia
Continous ECG first 24 hours an ECG every second day
Time frame: 7 days postoperative
Myocardial necrosis
Troponin taken every day postoperative
Time frame: 7 days postoperative
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