Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass

Yonsei University74 enrolled

Overview

The purpose of this study is to study the effect of remote ischemic preconditioning on acute kidney injury in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.

Hypothesis : RIPC using tourniquet might be a simple technique with the benefit to provide renal protection without disturbing operating procedure and prolongation of total operating time.

Study Type

INTERVENTIONAL

Purpose

PREVENTION

Enrollment

Conditions

Heart Valve Disease

Interventions

Automated cuff-inflatorPROCEDURE

RIPC protocol consisted of three 10-min cycles of lower limb ischemia at an inflation pressure of 250 mmHg induced by an automated cuff-inflator placed on the upper leg with an intervening 10 min of reperfusion during which the cuff was deflated.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing complex valve surgery. Exclusion Criteria: * older than 80 years * those with left main disease \>50%, or hepatic or pulmonary disease * active infective endocarditis * left ventricular ejection fraction \<30% * myocardial infarction (MI) within 3 weeks * pre-existing renal dysfunction (serum creatinine (Cr) level \>1.4 mg/dl), and those with peripheral vascular disease affecting the lower limbs.

Data from ClinicalTrials.gov

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