Major surgery is still associated with a high rate of postoperative morbidity despite improved techniques in surgical management. Surgery-induced alterations of the immune system are well described and may play a role in the genesis of postoperative complications. It has been shown by several large scale clinical trials, that the use of immunonutrition in postoperative cancer surgery, trauma and critically ill patients resulted in an improved immunocompetence and/or reduced postoperatively infectious morbidity and/or length of hospital stay.The pre-operative regimen was between 5 to 7 days of treatment. The aim of this trial is to evaluate if a shorter administration of 3 days pre-operatively would be beneficial as well.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
107
Oral Nutritional Supplement containing the amino acid arginine, omega-3 fatty acids, and nucleotides (RNA).
Kantonsspital Aarau
Aarau, Switzerland
Kantonsspital Baden
Baden, Switzerland
Lindenhof-Spital
Bern, Switzerland
Kantonsspital Liestal
Liestal, Switzerland
Kantonsspital St.Gallen
Sankt Gallen, Switzerland
Kantonsspital Schaffausen
Schaffhausen, Switzerland
Rate of post-operative complications
Time frame: On the day of discharge from hospital
Incidence of non-infectious complications
Time frame: On the day of discharge from hospital
Length of hospital stay
Time frame: On the day of discharge from hospital
Nutritional status evaluation
Time frame: On the day of discharge from hospital
Rate of post-operative infectious complications
Time frame: On the day of discharge from hospital
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