Increasing the Yield of Blood Cultures in Neonates

Shaare Zedek Medical Center1,500 enrolled

Overview

The purpose of this study is to determine whether the use of a single blood sample of 1cc in an aerobic bottle will provide a better yield and time to positivity than 2 samples of 0.5 cc in 2 (aerobic and anaerobic) bottles for blood cultures in neonates.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

1,500

Conditions

Bacteremia

Interventions

1cc of blood in a single aerobic culture bottleOTHER

The efficacy of using 1cc of blood in a single aerobic bottle for cultures in neonatal bacteremia will will be compared with the traditional 0.5cc of blood in 2 Bottles

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All blood cultures taken in the NICU during the study period. Exclusion Criteria: * Bacteria that are normal flora of the skin such as Coagulase negative staphylococci or Streptococci Viridans are considered, except if grown in two sets of cultures or in the presence of laboratory and clinical indices of infection.

Outcomes

Primary Outcomes

Non Inferiority of 1 cc blood culture in a single aerobic bottle instead of 0.5 cc for 2 bottles.

Time frame: 6months

Secondary Outcomes

utility of the routine use of anaerobic bottle for blood cultures in newborns

Time frame: 6 months

Comparison of time to positivity of 1 cc blood culture in a single aerobic bottle instead of 0.5 cc for 2 bottles (aerobic and anaerobic)

Time frame: 6 months

Data from ClinicalTrials.gov

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