OPTIMOX1 in Chinese mCRC Patients

Inclusion Criteria: * Patients with histologically confirmed adenocarcinoma of the colon or rectum * Unresectable metastases * At least one bidimensionally measurable lesion of ≥ 1 cm * No previous chemotherapy for metastatic disease; Completed at least more than 1 year oxaliplatin therapy for adjuvant treatment * 18-75 years old * ECOG 0-2 * Life expectancy greater than 3 months * Hemogram: WBC≥4.0 X109/L, ANC ≥2 X109/L, PLT ≥100 X109/L, Hb ≥90g/L, * Adequate Renal Function * Adequate Liver Function * Signed informed consent before the treatment Exclusion Criteria: * Patients with previous oxaliplatin based adjuvant chemotherapy within 1 Year * Completely or partially bowel obstruction * Presence of peripheral neuropathy (CTC\>grade I) * Severe mental disorder * CNS metastasis * With other severe disease: uncontrolled active infectious disease, uncontrolled hypertension, heart infarction within 1 year, uncontrolled high-risk arrhythmia, unstable angina * With other malignant disease previously or concurrently * Receive other anti-tumor treatment * Pregnant or lactating women, or women of child bearing potential without contraceptive method.