The objective of the study is to determine if CPAP applied within less than 15 min of life in the DR reduces the necessity of mechanical ventilation and surfactant during the first 5 days of life.
A multicenter prospective cohort of inborn preterm infants, born at 8 public university NICU in Brazil, with birthweight 1000-1499 g, without malformations, not intubated at 15 minutes of life. Preterm infants will be randomly assigned at birth to an early treatment group (DR-CPAP), in which CPAP of 5 cm water pressure is applied within 15 minutes after birth by Neopuff, or to a routine group (RG), in which CPAP is applied when indicated by the assistant physician. After transfer to the NICU, nasal CPAP will be maintained with Hudson prongs
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
200
CPAP of 5 cm water pressure will be applied within 15 minutes after birth by Neopuff
Necessity of mechanical ventilation and surfactant during the first 5 days of life
Time frame: 5 days
Maternal and infant characteristics associated with CPAP failure during the first 15 minutes of life
Time frame: 15 minutes
Incidence of pneumothorax, interstitial emphysema, ductus arteriosus, peri- intra-ventricular hemorrhage, sepsis, necrotizing enterocolitis
Time frame: 30 days
Oxygen use
Time frame: 28 days
Oxygen use
Time frame: 56 days
Oxygen use
Time frame: 36 weeks of corrected age
Retinopathies of prematurity
Time frame: Hospital stay
Death during hospitalization
Time frame: Hospital stay
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