Role of Angiotensin II in Insulin-induced Microvascular Activity

Maastricht University Medical Center18 enrolled

Overview

In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Insulin Sensitivity Microcirculation

Interventions

Angiotensin IIDRUG

Angiotensin II

PhenylephrineDRUG

Phenylephrine

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1.18-60 years 2.Caucasian 3.Blood pressure \<140/90 mmHg. Exclusion Criteria: 1. Obesity (BMI\>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use \>4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses

Locations (1)

Maastricht University Medical Centre

Maastricht, P.o. Box 5800, Netherlands, Netherlands

Outcomes

Primary Outcomes

functional recruitment of capillaries in the skin

Time frame: January 2009

Secondary Outcomes

perfused capillary density in the nailfold

Time frame: January 2009

Endothelium- (in)dependent vasodilatation of finger skin microcirculation

Time frame: January 2006

Insulin sensitivity

Time frame: January 2009

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.