Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

Chungnam National University1,224 enrolled

Overview

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Study Type

OBSERVATIONAL

Enrollment

1,224

Conditions

Single-nucleotide Polymorphism (SNP) for Glaucoma

Interventions

SNP analysis of the DNAGENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Eligibility

Sex: ALLMin age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of primary open angle glaucoma Exclusion Criteria: * Primary open angle glaucoma combined with congenital ocular disease * Primary open angel glaucoma combined with other ocular disease * Significant systemic disease other than systemic hypertension and diabetes

Locations (1)

Chungnam National University Hospital

Daejeon, South Korea

Outcomes

Primary Outcomes

genotyping for the SNP associated with primary open angle glaucoma

Time frame: one year

Secondary Outcomes

genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns

Time frame: one year

Data from ClinicalTrials.gov

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