Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy

Yonsei University84 enrolled

Overview

The purpose of this study is to study the effect of intraoperative magnesium on remifentanil-induced postoperative hyperalgesia after thyroidectomy

Study Type

INTERVENTIONAL

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Hyperalgesia

Interventions

remifentanil, MgSO4DRUG

Patients undergoing thyroidectomy will be randomly assigned to one of three groups. Remifentanil will be infused intraoperatively at 0.05 ㎍/㎏/min (group Ⅰ) or 0.2 ㎍/㎏/min (group Ⅱ \& Ⅲ). Patients in group Ⅲ will be received 30 ㎎/㎏ MgSO4 at the induction of general anesthesia followed by a maintenance infusion of 10 ㎎/㎏/hr intraoperatively until skin closure.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing thyroidectomy, * Age 20-65, * American Society of Anesthesiologists physical status classification I or II. Exclusion Criteria: * History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs, * History of drug \& alcohol abuse, * Psychiatric disorder, * Use of opioids within 24hrs, * Renal disease with decreased GFR, * Neuromuscular disease, Severe cardiac disease.

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs

Time frame: postoperative 48 hrs

Data from ClinicalTrials.gov

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