Effects of Inulin on Satiety and Food Intake

Maastricht University Medical Center30 enrolled

Overview

To assess the effect of inulin on appetite profile ratings, food intake and satiety hormones.

Based upon a slower digestion and the fermentation in the intestinal tract, food containing soluble dietary fibres, such as inulin, is hypothesized to be more satiating, and to limit energy intake, in humans. Does supplementation of inulin (at 2 dosages) versus placebo over 13 consecutive days in normal to overweight men and women, lead to an increase in satiety, a reduction in food intake and stronger postprandial increases in GLP-1 and PYY?

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Obesity

Interventions

inulinDIETARY_SUPPLEMENT

10gram/day inulin for 13-day treatment

inulinDIETARY_SUPPLEMENT

16gram/day inulin for 13-day treatment

placeboDIETARY_SUPPLEMENT

16gram/day maltodextrin (placebo) for 13-day treatment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 and 60 years * BMI between 23 and 28 kg/m2 * dietary unrestraint (TFEQ: F1\<9) Exclusion Criteria: * age under 18 and above 60 years * BMI under 23 and above 28 kg/m2 * dietary restraint (TFEQ: F1\>9) * use of medication * pregnant or breastfeeding

Locations (1)

Maastricht University

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

food intake

Time frame: on testday 0 and 13

Secondary Outcomes

appetite profile ratings

Time frame: on test day 0, 8 and 13 (at 16 time points)

satiety hormones (GLP-1 and PYY)

Time frame: on test day 0 and 13 (at 9 time points

Data from ClinicalTrials.gov

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