The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
The patients will follow a rich in MUFA diet without a physical activity program.
patients will follow for two months a high fibre/ low glycemic index diet with a physical activity program.
Patients will follow for two months a rich in MUFA diet with a physical activity program.
Patients will follow for two months a high fibre/low glycemic index diet without a physical activity program.
Liver fat content
Time frame: 0 and 8 weeks
postprandial lipids metabolism
Time frame: 0 and 8 weeks
changes in body fat distribution
Time frame: 0 and 8 weeks
oxidative stress and inflammation
Time frame: 0 and 8 weeks
adipose tissue lipolytic activities
Time frame: 0 and 8 weeks
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