Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides

Inclusion Criteria: * Healthy as determined by a responsible and experienced physician. * Male between 18 and 65 years of age inclusive, at the time of signing the informed consent. * The subject has a body weight of more than or equal to 50 kg and a BMI 18.5 to 30 kg/m2. * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. Exclusion Criteria: * Subjects with very fair skin type. * Presence on either forearm of tattoos, naevi, scars, keloids, hyperpigmentation, excessive hair or any skin abnormalities that may, in the opinion of the investigator, interfere with study assessments. * Subjects with a history of keloids, skin allergy, hypersensitivity or contact dermatitis, including previous reactions to dressings to be used in the study. * Subjects with a history of lymphangitis and/or lymphoedema. * Subjects with a history of HIV infection, hepatitis B or C. * A positive pre-study drug/alcohol screen. * Use of prescription or non-prescription drugs, including ergot derivatives e.g. dihydroergotamine (Dihydergot), vitamins, herbal and dietary supplements (including St John's Wort) within whichever is the longer period of 14 days or 5 half-lives (if known) prior to the first challenge day, unless in the opinion of the Investigator and GSK Medical Monitor the medication will not interfere with the study procedures or compromise subject safety. * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the dosing day in the current study: 90 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within 56-day period. For part C only: * QTcB or QTcF \>450 msec, based on average QTc value of triplicate ECGs obtained over a brief recording period, if the first measurement shows abnormal QTc value. * History of sensitivity to azithromycin, macrolide/ketolide antibiotics or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.