Study to Evaluate the Role of Itopride HCI in Patients With Irritable Bowel Syndrome With Predominant Constipation

Inclusion Criteria: 1. Male or female patient fulfilling the Rome III criteria for IBS-C 2. Signed informed consent at screening visit Exclusion Criteria: 1. Patients having significant diarrhea at least 25% of the time during the past 3 months 2. Patients having alarm symptoms or signs 3. Chronic diarrhea 4. History of gastrointestinal haemorrhage, mechanical obstruction or perforation 5. Patient with clinically relevant ECG abnormalities (prolonged QT interval) 6. Active psychiatric disorder that would interfere with the study objectives 7. Health conditions (e.g. age related impairment of cognitive functions) that would interfere with the study objectives or might impair the compliance of the patient 8. Severe hepatic, renal, cardiac, metabolic, haematological or malignant diseases (including prolactin dependent tumours) or clinically relevant deviations in laboratory values (AST/ALT greater than twice the upper limit of normal, serum creatinine \* 2 mg/dl \[177 µmol/l\] according to the medical judgement of the investigator 9. Patient with hypokalemia (serum potassium \< 3.5 mmol/l). 10. History of any known hypersensitivity to the ingredients of the investigational drug 11. Pregnancy or lactation 12. Women with childbearing potential who do not apply a medically accepted method of contraception.