Antiemetic Efficacy and Safety of Dexamethasone in Obstetric Surgical Patients

Makerere University250 enrolled

Overview

This is a randomised controlled double blinded clinical trial to determine the antiemetic efficacy and safety of either 8 mg of dexamethasone or normal saline (placebo) given 1 hour before induction of either spinal or general anaesthesia in 2 arms (of 150 each).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

250

Conditions

Postoperative Nausea and Vomiting

Interventions

dexamethasoneDRUG

single Bolus dose of dexamethasone 8mg

normal salineOTHER

2 ml 0.9% saline

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * all woman above 18 years old presenting for obstetric surgery and have consented to study. Exclusion Criteria: * refusal/unable to consent, * younger than 18 years old, * hypertensive, * diabetic, * preeclamptic, * sepsis, * ASAIIIE plus.

Locations (1)

Mulago National Refferal Hospital

Kampala, Uganda

Outcomes

Primary Outcomes

presence of post nausea and or vomiting

Time frame: 24 hours

Secondary Outcomes

perianal itching

Time frame: 24 hours

hyperglycemia

Time frame: 24 hours

hypertension

Time frame: 24 hours

Data from ClinicalTrials.gov

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