A Study of Endostar Combined With Chemotherapy Followed by Endostar Maintenance Therapy to Treat Advanced Non-small Cell Lung Cancer (NSCLC)

Inclusion Criteria: * Histological or cytological diagnosis of inoperable stage IIIB/IV NSCLC * At least one measurable lesion * Age of 18-75 years * Life expectancy \> 3 months * ECOG performance status 0-2 * Adequate hematologic, renal, and hepatic function Exclusion Criteria: * Prior systemic chemotherapy for NSCLC * Evidence of any unstable diseases (serious infection, grade 4 hypertension, unstable angina, congestive heart-failure, compromised renal or hepatic function, nonhealing wound or bone fracture) * Concurrent anticoagulation therapy * Evidence of bleeding diathesis or coagulopathy * Pregnant or lactating women * Allergic to E.coli preparation