Posttraumatic Hypopituitarism - Incidence, Predictors and Test Validity

Rigshospitalet, Denmark463 enrolled

Overview

The purpose of the study is to estimate the incidence of posttraumatic hypopituitarism, and to identify predisposing factors in order to establish a rational responsible socioeconomic screening program.

Study Type

OBSERVATIONAL

Enrollment

463

Conditions

Traumatic Brain Injury Hypopituitarism

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * International Classification of Diseases (ICD) 10 code S06.0-06.9 * Age 18 - 65 years at time of traumatic brain injury * Duration of hospitalization \> 24 hours. Exclusion Criteria: * Known pituitary disease * Clinically significant liver or renal disease * Breast-feeding * Pregnancy * Alcohol or drug abuse

Outcomes

Primary Outcomes

Hypopituitarism

Time frame: 5 years

Secondary Outcomes

Quality of life

Time frame: 5 years

Fatigue

Time frame: 5 years

Hypopituitary specific symptoms

Time frame: 5 years

Data from ClinicalTrials.gov

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