The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals

Bayside Health42 enrolled

Overview

The purpose of this study is to determine the effect of slowing heart rate upon both central and peripheral blood pressures using a medication called Ivabradine which slows heart rate without affecting heart contraction, and to compare the effects of ivabradine to a traditional blood pressure lowering medication called metoprolol (which is a beta-blocker).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Blood Pressure

Interventions

ivabradineDRUG

metoprololDRUG

placeboDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 - 25 years OR * Aged \> 60 years Exclusion Criteria * Chronic disease * Unable to give informed consent * Treated or untreated systemic arterial hypertension (SBP \> 160 mmHg and/or DBP \> 90 mmHg) * Resting bradycardia (heart rate \< 60 beats/minute) * Pregnancy or active lactation

Outcomes

Primary Outcomes

central and peripheral arterial and pulse wave velocity

Time frame: baseline, and 4 hours following the administration of placebo, metoprolol or ivabradine.

Secondary Outcomes

Central pulse pressure

Time frame: Baseline measurements of central and peripheral arterial and pulse wave velocity will be made at baseline, and 4 hours following the administration of either placebo, metoprolol or ivabradine.

Data from ClinicalTrials.gov

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