A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies

Phase 4TerminatedNCT01030263

Mayo Clinic18 enrolled

Overview

We wish to determine whether biopsies obtained with the technique of fluorescence-aided confocal endomicroscopy will detect more patients with specialized columnar epithelium than random biopsies among patients with Barrett's esophagus who are being monitored with endoscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Barrett's Esophagus

Interventions

Fluorescence-aided confocal endomicroscopy guided biopsy.OTHER

Fluorescence-aided confocal endomicroscopy guided biopsy.

Random four-quadrant biopsies.OTHER

Random four-quadrant biopsies.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age at least 18. * Barrett's esophagus * Acid suppressive therapy * Endoscopic surveillance Exclusion Criteria: * Pregnancy or lactation * Allergy to fluorescein * Endoscopic esophagitis Los Angeles classification A to D * Mucosal irregularity or nodules suspicious for dysplastic or cancerous lesion * Obvious mass lesions or cancer

Locations (1)

Mayo Clinic

Scottsdale, Arizona, United States

Outcomes

Primary Outcomes

Whether specialized columnar epithelium was detected.

Time frame: At biopsy on Day 0.

Data from ClinicalTrials.gov

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