Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients

Julius-Maximilians University50 enrolled

Overview

Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.

In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Coronary Artery Disease

Interventions

PETN, ISDNDRUG

Oral dosing of organic nitrates PETN 2x 80mg per day ISDN 2x40mg per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary artery disease, 2- or 3-vessel disease Exclusion Criteria: * Acute myocardial infarction, acute heart failure, cancer, acute infections

Locations (1)

Julius-Maximilians University

Würzburg, Bavaria, Germany

Outcomes

Primary Outcomes

Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells

Time frame: Baseline and after 14d

Data from ClinicalTrials.gov

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