The objective is to analyse the changes in the adipose tissue hystological features and the adipogenesis gene expression and related to inflammation after 48 and 96 weeks after the change from AZT+3TC+ABC (Trizivir®) to a monotherapy treatment with LPV/r (Kaletra®)
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
7
Each tablet of Kaletra contains 200 mg of Lopinavir and 50mg of ritonavir. The patients will take two tablets of Kaletra bid.
Fundación Jiménez Díaz
Madrid, Madrid, Spain
Hospital Clínico San Carlos
Madrid, Madrid, Spain
Change in those representative gene expression of adipose tissue toxicity (variable established from those gene involved in adipogenesis, inflammation and metabolism. This gene expression will counted)
Time frame: 48 and 96 weeks
Changes in physical fat deposits
Time frame: Baseline, 24, 48, 72 and 96 weeks
Changes in leptine and adiponectine plasma levels
Time frame: baseline, 24, 48, 72 and 96 weeks
Patients percentage with virologic response (ARN-VIH< 50 copies/mL)
Time frame: 48 and 96 weeks
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