Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
Group M received 50 mg/kg of magnesium sulphate on 100 ml of isotonic saline over 10 minutes during the anesthesia induction, followed by the 15 mg/kg/h by continuous infusion during the operation
Group S received the same volume of isotonic saline as same method.
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
thromboelastography (TEG) analysis
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: twice
hemoglobin level
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: twice
platelet count
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: twice
international normalized ratio of prothrombin time (INR-PT)
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: twice
activated partial thromboplastin time (aPTT)
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: tiwce
serum magnesium level
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
Time frame: twice
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