Surgery or Chemoradiation for Esophageal Cancer

Chinese University of Hong Kong40 enrolled

Overview

The aim of this study is to compare outcomes in patients with operable squamous carcinoma of the esophagus who have received either surgery or definitive chemoradiation (CRT).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Esophageal Cancers

Interventions

EsophagectomyPROCEDURE

The patients will receive standard open esophagectomy with two-field lymphadenectomy

Definitive chemoradiationRADIATION

3-weekly cycles of cisplatin and 5-fluorouracil chemotherapy and radical radiotherapy delivered in a three-dimensional conformal mode (total of 50-60 Gy given in 25-30 fractions) will be given over a period 5-6 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Eligible patients had mid or lower thoracic esophageal cancers that were confirmed on histology to be a squamous cell carcinoma deemed to be resectable. Exclusion Criteria: * The investigators excluded those patients who had distant metastasis to solid visceral organs or local invasion into trachea, descending aorta, or recurrent laryngeal nerve. * Those patients who were older than 75 years or who had a serious premorbid condition or a poor physical status that compromised a thoracotomy were also excluded.

Outcomes

Primary Outcomes

Overall survival and disease-free survival

Time frame: 2 year and 5 year

Secondary Outcomes

Quality of life and function outcomes

Time frame: 2 year

Data from ClinicalTrials.gov

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