Our hypothesis is that 30 days of oral levofloxacin (FDA approved antibiotic) in patients with persistent viremia (BK virus found in blood) will impair progress to BK virus induced kidney damage by significantly decreasing or eliminating BK virus in the blood.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
43
500 mg tablet, daily, 30 days
no dose, tablet, daily, 30 days
Massachusetts General Hospital
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Lahey Clinic Medical Center
Percent Change From Baseline in BK Virus Copies at 3 Months
Percent change in BK virus copies/mL from Baseline to 3 months
Time frame: Baseline and 3 months
Number of Patients With >50% Reduction in BK Virus Copies
Number of patients with \>50% reduction in BK viral load at 6 months
Time frame: Baseline and 6 months
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Burlington, Massachusetts, United States
UMASS Memorial Medical Center
Worcester, Massachusetts, United States
Montefiore Medical Center
The Bronx, New York, United States
Fletcher Allen Health Care/University of Vermont
Burlington, Vermont, United States
University of Wisconsin Hospital
Madison, Wisconsin, United States