Risk Factors and Molecular Genomics of U.S. Patients With Chronic Liver Disease and Hepatocellular Cancer

Inclusion Criteria: * For both experimental subjects and controls: 1. Patients between older than 18 years of age of all ethnic backgrounds and genders. 2. Patients with chronic liver disease * For Experimental Subjects Only: 1. Patients with HCC with a hepatic mass larger or equal to 5cm 2. Patients with HCC with a hepatic mass lesion confirmed by fine needle aspirate (FNA) or by pathology in the cases of surgical resection 3. Patients with HCC with a hepatic mass lesion with characteristic CT or MRI or angiographic appearance. * For Controls Only: Patients with chronic liver disease without evidence of HCC confirmed by either : 1\. A normal AFP level 2\. a negative imaging study (ultrasound, CT, or MR imaging). 3\. Negative liver cancer on explants. \*Exclusion Criteria: 1. Patients who declined to participate in the study 2. Patients with a history of HIV infection 3. Patients with concurrent advanced malignancy of non-hepatic origin. 4. Patients with significant use of androgenic steroid. 5. Patients with exposure to vinyl chloride.