Compare FOFLOX4 in Preoperative and Postoperative and Postoperative in Resectable Liver Metastasis Colorectal Cancer (MCC)

Inclusion Criteria: 1. Resectable liver metastasis from colorectal cancer(the distance from the tumor lower edge to anal more than 12cm),no visible extrahepatic metastatic tumors. Curable by resection, as determined by a surgeon and imaging physicians. The minimum of the liver metastases needs ≥2cm. Patients can be recruited if meet the conditions about: * Primary tumor had been removed of the metachronous liver metastasis patients and no residue from the eyes or microscope. * Primary tumor has been removed more than 1 month of the simultaneous liver metastasis patients. 2. Age of≥18 and ≤80 3. ECOG≤2 4. Signed written informed consent Exclusion Criteria: 1. Peripheral neuropathy(CTC\>1) 2. Had a neurological or mental disorders 3. Active infection 4. Allergy to Platinum-based and other drugs 5. Other acute diseases including infection, heart-disease(CHF, stable or unstable angina) 6. Pregnant or nursing patients