Biochemical Approach to Measuring Surgical Trauma

Hamilton Health Sciences Corporation

Overview

This study will examine the magnitude and time course of changes in circulating (serum and plasma) biomarker concentrations associated with musculoskeletal injury created by total knee replacement surgery. The sensitivity to injury will be characterized by the changes in mean serum concentration before and after surgery. Specificity for the injured state will be evaluated comparing the baseline to peak change (injury response) with the pre-surgery to follow-up baseline fluctuation (i.e. measurement noise).

Study Type

OBSERVATIONAL

Conditions

Total Knee Replacement

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria * Age 18 to 75 * No musculoskeletal injury requiring medical attention in the past 3 months other than entirely related to worsening symptoms of the operative knee or spinal level. * No musculoskeletal injury producing pain in the previous 2 weeks. * No inflammatory disease other than osteoarthritis) * No exercise with weights in the 2 weeks before surgery.

Locations (1)

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Outcomes

Primary Outcomes

Sensitivity and Specificity of biomarkers in response to tissue injury

Time frame: 7 days

Data from ClinicalTrials.gov

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