Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

Inclusion criteria 1. Aged between 4 months and 11 months at the time of randomization 2. Bodyweight ≥ 5 kg at the time of randomization 3. Provision of informed consent by parent or guardian 4. Intention to stay in the study area for the time of the study Exclusion criteria 1. Ongoing participation into another clinical study involving ongoing or scheduled treatment with medicinal products 2. Intent to reside outside of catchment area during the course of the study 3. Known hypersensitivity to the study drug randomized to 4. Known pre-existing hearing problem or neurological impairment 5. Known need at the time of randomization for concomitant prohibited medication 6. Suspected non-compliance with the follow-up schedule