Comparison of Tacrolimus and Myfortic Versus Tacrolimus and Sirolimus

Inclusion Criteria: * Non-HLA identical living donor kidney transplant patients Exclusion Criteria: * Patient has previously received or is receiving an organ transplant other than a kidney. * Patient is receiving an ABO incompatible donor kidney. * Recipient or donor is known seropositive for human immunodeficiency (HIV) or Hepatitis C virus, or Hepatitis B virus antigenemia. * Patient has a current malignancy or a history of malignancy (within the past 5 years), except non-metastatic basal or squamous cell carcinoma of the skin that has been treated successfully, or carcinoma in-situ of the cervix that has been treated successfully. * Patients with significant liver disease, defined as having during the past 28 days continuously elevated AST (SGOT) and/or ALT (SGPT) levels greater than 3 times the upper value of the normal range at our center. * Patient has uncontrolled concomitant infections and/or severe diarrhea, vomiting, active upper gastro-intestinal tract malabsorption or an active peptic ulcer or any other unstable medical condition that could interfere with study objectives. * Patient is currently participating in another clinical trial of an investigational drug in the 30 days prior to transplant. * Patient will be receiving any immunosuppressive agent other than those prescribed in the study. * Patient is unable to take medications orally or via nasogastric tube by the morning of the second day following completion of the transplant procedure (i.e., skin closure). * Patient is receiving or may require Warfarin, Fluvastatin, or herbal supplements during the study. * Concurrent use of Astemizole, Pimozide, Cisapride, Terfenadine, or Ketoconazole. * Patient has a known hypersensitivity to Tacrolimus, Thymoglobulin®, IL-2 receptor inhibitor monoclonal antibodies, Rapamune, Myfortic®, or corticosteroids. * Patient is pregnant or lactating. * Patients with a screening/baseline (or within 96 hours of transplant) total white blood cell count \<4000/mm3; platelet count \<100,000/mm3; fasting triglycerides \>400 mg/dl (\>4.6 mmol/L); fasting total cholesterol \>300 mg/dl (\>7.8 mmol/L); fasting HDL-cholesterol \<30 mg/dl; fasting LDL-cholesterol \>200 mg/dl. * Patient is unlikely to comply with the visits scheduled in the protocol. * Patient has any form of substance abuse, psychiatric disorder or a condition that, in the opinion of the investigator, may invalidate communication with the investigator. * If Tacrolimus cannot be instituted for longer than 5 days postoperatively.