Safety and Tolerability of Anti-IL-20 in Subjects With Rheumatoid Arthritis

Inclusion Criteria: * Informed consent obtained before any trial-related activities * A diagnosis of rheumatoid arthritis made at least 3 months prior to screening * Active rheumatoid arthritis, characterised by a DAS28 equal or above 3.2 * Methotrexate treatment (stable dose, equal or below 25 mg/week) for at least 4 weeks prior to study start (subjects receiving stable doses of oral corticosteroids, and/or non-steroidal anti-inflammatory drugs and/or acetaminophen and/or opioids according to prescribed recommended doses can be included) * Male subjects and female subjects of non-child bearing potential Exclusion Criteria: * Body mass index (BMI) less than 18.5 or above 35.0 kg/m2 * Subjects with chronic inflammatory autoimmune disease other than rheumatoid arthritis * History of or current inflammatory joint disease other than rheumatoid arthritis * Chronic or ongoing infectious disease requiring systemic anti-infectious treatment within 2 weeks prior to study start * Past or current malignancy (as judged by the investigator) * Clinically significant cardiac or cardiovascular disease * Positive for human immunodeficiency virus (HIV), hepatitis or tuberculosis * Blood donation or blood loss of more than 0.45L within 2 months prior to study start, or longer if required by local regulations * Breast-feeding women