Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

The Cleveland Clinic108 enrolled

Overview

The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

108

Conditions

Aging Alzheimer's Disease

Interventions

Exercise TrainingOTHER

Aerobic exercise training program designed by the Cardiac Rehabilitation department

Cognitive TrainingOTHER

Based on cognitive training program Brain Fitness®

Flexibility TrainingOTHER

Non-aerobic flexibility training program designed by the Cardiac Rehabilitation department

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * First or Second-degree relative of someone with Alzheimer's Disease * Not currently engaging in regular exercise * Able to undergo an MRI * Fluent in English Exclusion Criteria: * Neurological illnesses/conditions * Medical illness/conditions that may affect brain function * Any unstable or severe cardiovascular disease or asthmatic condition * Severe depressive symptoms * Inability to walk unassisted

Locations (1)

The Cleveland Clinic

Cleveland, Ohio, United States

Outcomes

Primary Outcomes

Brain activation patterns measured by functional MRI

Time frame: baseline and 12 weeks

Secondary Outcomes

Neuropsychological Testing

Time frame: baseline and 12 weeks

Exercise assessment

Time frame: baseline and 12 weeks

Data from ClinicalTrials.gov

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