Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria

University of Pavia120 enrolled

Overview

The main objective of this study is to assess the extent and trend in time of antiproteinuric effect as well as that antihypertensive effect of aliskiren 300 mg / d versus ramipril 10 mg daily in hypertensive patients with type 2 diabetes and microalbuminuria. The investigators will also evaluate: 1. Average of 24 hours, as determined by ABPM, systolic and diastolic blood pressure checks at various visits 2. Average daytime, as determined by ABPM, systolic and diastolic blood pressure checks at various visits 3. Average night, as determined by ABPM, systolic and diastolic blood pressure checks at various visits

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

120

Conditions

Hypertension Type 2 Diabetes

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * blood pressure \> 130/80 \<180/105 mmHg at the end of the wash-out * type 2 diabetes mellitus well controlled by medication and / or compliance with diet (HbA1c \<7%) * microalbuminuria in the upper range of normal (\> 200 \<300 mg/24 h) Exclusion Criteria: * Pregnancy, lactation or women of childbearing age * Sitting diastolic blood pressure e 105 mmHg or systolic pressure e 180 at the end of the period of wash-out * History of hypertensive encephalopathy or cerebrovascular accident within 6 months * Secondary hypertension * Heart Failure * Myocardial infarction within 6 months * Angina pectoris, clinically significant valvular disease or arrhythmia * Alteration indices of liver function or renal * Known hypersensitivity to ACE inhibitors * All other physiological or pathological condition in the opinion of the physician may affect the evaluation of the parameters under study

Outcomes

Primary Outcomes

Antiproteinuric effect as well as antihypertensive effect of aliskiren 300 mg / daily versus ramipril 10 mg daily in hypertensive patients with type 2 diabetes and microalbuminuria.

Time frame: 3 months

Secondary Outcomes

Average of 24 hours by ABPM, systolic and diastolic blood pressure

Time frame: 3 months

Average daytime, systolic and diastolic blood pressure

Time frame: 3 months

Average night, systolic and diastolic blood pressure

Time frame: 3 months

Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts