Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy

Aristotle University Of Thessaloniki200 enrolled

Overview

Hypocalcemia is one of the most frequent complications of total thyroidectomy, a procedure used for benign as well as malignant conditions of the thyroid gland. Postoperative hypocalcemia is usually caused by hypoparathyroidism. Vitamin D is implicated in calcium metabolism as it increases intestinal calcium transport and regulates parathormone production. Aim of the present study is to evaluate preoperative vitamin D levels as a prognostic factor for postoperative hypocalcemia and hypoparathyroidism.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Hypocalcemia Hypoparathyroidism Vitamin D Deficiency Thyroidectomy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient is over 18 years old 2. Patient scheduled for total thyroidectomy 3. Patient signs and dates a written informed consent form (ICF) and indicates an understanding of the study procedures Exclusion Criteria: 1. Primary hyperparathyroidism 2. Primary hypoparathyroidism 3. Chronic Renal Failure 4. Hypoalbuminemia 5. Neck irradiation 6. Systematic Diseases (e.g., infections) 7. Thyroid or parathyroid cancer 8. Osteoporosis 9. Drugs that influence calcium metabolism (vitamin D analogues, oral calcium supplements, biphosphonates, teriparatide, thiazide diuretics)

Outcomes

Primary Outcomes

Impact of preoperative vitamin D levels on postoperative hypocalcemia after total thyroidectomy.

Time frame: 24 hours postoperatively

Secondary Outcomes

Impact of preoperative vitamin D levels on parathyroid function after total thyroidectomy.

Time frame: 24 hours postoperatively

Central Contacts

Theodossis S Papavramidis, MD, PhD

CONTACT

00302310993197 papavramidis@hotmail.com

Olympia E Anastasiou, MD