White Matter Pathology in Parkinson's Disease (PD)

Tel-Aviv Sourasky Medical Center120 enrolled

Overview

The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown. We hypothesize that sub-clinical WM pathology may be a major contributing factor to PIGD-PD. We will compare two groups of patients with Parkinson's disease (PD): those with PIGD and patients with dominant tremor (n=120)to assess the role of brain WM changes.

To compare brain WM burden using MRI in PD patients with and without PIGD. Diffusion tensor imaging (DTI) analysis techniques will be applied.We will quantify PIGD-related symptoms including cognitive function, balance and gait and their associations with MRI findings.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

White Matter Lesions Postural Instability Gait Disorders

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosis of idiopathic PD, as defined by the UK Brain Bank criteria 2. Age between 50 and 80 years 3. Hoehn and Yahr stage II-III 4. On anti-parkinsonian medications 5. Mini-Mental State Exam score ≥ 25 Exclusion Criteria: 1. Brain surgery in the past including implanted Deep Brain Stimulation 2. Clinically significant co-morbidities likely to affect gait e.g., acute illness, significant rheumatic, orthopedic disease, dementia, or major depression 3. Unable to walk independently 4. Inability to comply with the protocol

Locations (1)

Laboratory for Gait and Neurodynamics, Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Central Contacts

Nir Giladi, MD

CONTACT

+972-3-6974790 ngiladi@tasmc.healht.gov.il

Talia Herman, MSc

CONTACT

+972-3-6974958 talit@tasmc.health.gov.il

Data from ClinicalTrials.gov

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