A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers

Inclusion Criteria: * Subjects may be of any race and gender within the age range of 18 to 40 years inclusive * All female subjects must be of non-childbearing potential. For the purposes of this study, this is defined as the subject being amenorrheic for at least 12 consecutive months, or at least 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy, or women who underwent tubal ligation. For women in menopause, menopausal status will be confirmed by demonstrating levels of follicle stimulating hormone (FSH) 40 - 138 mIU/ml and oestradiol \< 20 pg/ml at entry, unless this information is available in the subject's medical record. In the event a subject's menopause status has been clearly established (for example, the subject indicates she has been amenorrheic for 10 years), but FSH and/or oestradiol levels are not consistent with a post-menopausal condition, determination of subject eligibility will be at the discretion of the principal investigator following consultation with the sponsor and Medical Monitor * All male subjects and their partners must agree to use double-barrier birth control or abstinence while participating in the study and for 12 weeks following the last dose of study drug * Comprehension of the nature and purpose of the study and compliance with the requirement of the entire protocol * Willingness and ability to provide written informed consent to participate in the study * Subject is not taking any concomitant medications which may be associated with thrombosis (e.g., estrogens) * Have a normal 12-lead ECG or one with changes considered to be clinically insignificant on medical review. QTc must be ≤430msec for males and ≤450msec for females * No prior history of disease markers for hepatitis B and C virus * Body Mass Index (BMI) 18-32 kg/m\^2 (inclusive) * Non-smoking status as verified by urinary cotinine levels below 500ng/mL at the screening visit. This can include ex-smokers who have given up smoking for \>5 years. * Absence of significant disease or clinically significant abnormal laboratory values on the laboratory evaluations, medical history or physical examination during screening; normal end organ function, as determined by the Principal Investigator * Ability to communicate in person and by telephone in a manner that allows all protocol procedures to be carried out safely and reliably in the opinion of the investigative site staff * Ability to swallow 8 capsules of study medication with 400 mL of water Exclusion Criteria: * Any major illness in the past three months or any ongoing chronic medical illness which in the opinion of the PI or Medical Monitor could risk subject safety or interpretation of the results * History of congenital or acquired coagulopathy, including a history of prior venous thrombophlebitis/thromboembolism * Family history of hypercoagulable state * History of bleeding diathesis * Use of anti-platelet agents other than low dose aspirin, (81 mg per day or equivalent) and/or anti-coagulant medications * Any condition leading to venous stasis, such as varicose veins or congestive heart failure * Any surgery of the lower extremity during the last 6 months, except for simple excisions of skin lesions * Air or other confined travel in excess of two hours within the week prior to enrolment or anticipated at anytime during the study * History of cancer except non-metastatic, non-melanoma skin cancer or carcinoma-in-situ * History of renal or liver impairment, including nephrotic syndrome * Presence of pedal edema * History of gastro-intestinal surgery or has a current gastrointestinal disease which may influence drug absorption * History, within 3 years, of drug abuse (including benzodiazepines, opioids, amphetamine, cocaine, and THC) or a positive drug result at the screening visit * A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of Screening * A positive test for HIV antibody * History of alcoholism, and/or is currently drinking more than two drinks per day on a regular basis (one glass of wine, half a pint of beer, one measure of a spirit) * Participation in a clinical trial within the past three months (defined as three months from the date of last dose of an investigational medicinal product) * History of difficulty in donating blood or accessibility of veins in left or right arm * Blood donation (one unit or 350 mL) within one month prior to receiving test material * Use of herbal products, over-the-counter medication or prescription drug therapy for which 5 times the half-life is longer than 21 days (i.e., the screening Period) prior to enrolment into the study. Subjects must also refrain from taking herbal products for the duration of the study * History of a significant physical injury in the past 6 months that resulted in immobilization, impaired ambulation or abnormal range of motion * History of neuromuscular disease * A positive pre-study drug/alcohol screen * A documented history of claustrophobia and/or in vivo ferrous material which will interfere with magnetic resonance examinations * Subject is exercising more than 30 minutes per session twice weekly