Genetic Basis of Odor Discrimination

Rockefeller University512 enrolled

Overview

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Study Type

OBSERVATIONAL

Enrollment

512

Conditions

Non-smokers

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-50 2. Current non-smokers Exclusion Criteria: 1. Current smokers 2. Allergy to fragrances or smells of any kind 3. Active head cold, upper respiratory infection, or seasonal nasal allergies 4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal. 5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Locations (1)

The Rockefeller University

New York, New York, United States

Outcomes

Primary Outcomes

Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors

Time frame: 3 years

Secondary Outcomes

concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors

Time frame: 3 years

Data from ClinicalTrials.gov

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