QUILT-3.019: Phase 2 Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer

INCLUSION CRITERIA: * Age: \>/= 18 * Diagnosis: * Histologically confirmed recurrent, locally advanced unresectable or metastatic adenocarcinoma of the pancreas who have progressed after front line chemotherapy, OR * Histologically confirmed metastatic colorectal adenocarcinoma who have progressed after at least 2 standard chemotherapy regimens. * Tumor sections must stain \>/= 20% positive for NPC-1C antibody/antigen target * Measurable disease (by RECIST) * Karnofsky performance status of \>/= 50% * Laboratory Function (within 21 days of receiving first dose of study drug): * Hemoglobin \> 8.5 g/dL, or on stable doses (hematocrit stable within 1 gram and dose stable for one month) of erythropoietin or similar medication. * Absolute neutrophil count (ANC) \>/= 1,500/mm3 * Platelets \>/= 50,000/mm3 * Total bilirubin \</= 2.0 mg/dL * ALT and AST \</= 2.5 times the ULN, or, if the patient has liver metastases, \</= 5 times the ULN * Creatinine \</= ULN * Voluntary written informed consent before performance of any study-related procedure that is not part of normal medical care. * Expected to be able to remain on a study protocol for at least 8 weeks. * Is post-menopausal, surgically sterilized, or willing to use acceptable methods of birth control for the duration of the study. Male subject agrees to use an acceptable barrier method for contraception during the study. EXCLUSION CRITERIA: * Has history of disseminated or uncontrolled brain metastases or central nervous system disease. * Ascites with abdominal distention. * Mechanical, non-reversible reason for not being able to eat, or have a likelihood of developing malignant bowel obstruction during the course of the induction phase of treatment; subjects with uncomplicated J-tubes will not be excluded. * Any major surgery within four weeks of enrollment. * Uncontrolled concomitant illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia. * Has another serious medical illness, including a second malignancy, or psychiatric illness that could, in the Investigator's opinion, potentially interfere with the completion of treatment according to this protocol. * Pregnant or breast-feeding. * Any chemotherapeutic agents or corticosteroids within 2 weeks of study entry or biologic treatment within 4 weeks of study entry. * Use of any high risk medications that prolong the QT/QTc interval. * History of allergic reaction to Erbitux greater than grade 1. * Uncontrolled diabetes. * Prior history of a documented hemolytic event. * Receiving warfarin.