Gut Oxygenation and Laparoscopy

University of Milano Bicocca40 enrolled

Overview

Patients with left-colon cancer will be randomized to laparoscopic or laparotomic operation. during surgery and for 6 days after operation, intestinal oxygen tension and ischemia-reperfusion injury markers will be evaluated to understand if pneumoperitoneum is associated with reduced splanchnic blood flow and ischemia-reperfusion injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Laparoscopy Laparotomy Oxygenation,Ischemia-Reperfusion Injury

Interventions

LaparoscopyPROCEDURE

Laparoscopic Left-Colectomy

left colectomy by laparotomyPROCEDURE

PatientS will be operated by laparotomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Proven Cleft Colon Cancer, Signed Informed Consent Exclusion Criteria: * Emergency surgery, * Cancer infiltrating adjacent organ (at CT scan), * Severe cardiovascular (New York Heart Association class \> 3 ), * Respiratory (arterial PO2 \< 70 mmHg), * Renal (plasma creatinine \> 3 MG/dL) or hepatic (Child C) dysfunction

Locations (1)

San Gerardo Hospital

Monza, Italy

Outcomes

Primary Outcomes

Intestinal oxygenation

Time frame: 7 DAYS

Secondary Outcomes

Ischemic reperfusion injury

Time frame: 7 DAYS

Data from ClinicalTrials.gov

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