Ultrasound Guided Aspiration of Hydrosalpingeal Fluid and IVF-ET Outcomes

Cairo University110 enrolled

Overview

The aim of this study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .

A Cochrane review of prospective randomized trials of laparoscopic salpingectomy confirmed the beneficial effect of laparoscopic salpingectomy on IVF ET outcomes in patients with hydrosalpinges. Surgery is not usually safe especially in patients with extensive adhesions, morbid obesity and previous multiple laparotomies. Other less invasive options for patients with hydrosalpinges as ultrasound guided aspiration of hydrosalpingeal fluid, antibiotics and hysteroscopic occlusion of fallopian tube were studied in order to find an alternative to salpingectomy. Although these methods are simple and getting popular,current data are inadequate to recommend these treatment options instead of salpingectomy. The aim of this study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

110

Conditions

Infertility

Interventions

ultrasound guided aspiration of hydrosalpingeal fluidPROCEDURE

Under deep sedation, the retrieval of oocytes is done and then an aspiration needle is inserted into the hydrosalpinx under ultrasonographic guidance and suction is applied to aspirate the hydrosalpingeal fluid completely . If there are bilateral hydrosalpinges, the process is repeated on the opposite side.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 37 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with unilateral or bilateral hydrosalpinges visible by ultrasound * Age between 18 - 37 years * Period of infertility \> 1 year * Body mass index between 19-29 * Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin concentrations * Normal recent semen analysis (according to World Health Organization criteria) Exclusion Criteria: * Uterine fibroid requiring surgical removal * Endometriosis * Male factor of infertility requiring ICSI * Previous IVF cycles * History of recurrent miscarriage * Endocrinologic disorders * Presence of systemic disease contraindicating pregnancy

Locations (1)

Ahmed Elgazzar hospital , Assisted conception unit

Giza, 35 Eleshreen Saint King Faisal., Egypt

Outcomes

Primary Outcomes

The Number of Participants Who Achieved Clinical Pregnancy in a Transfer Cycle

The Number of Participants Who Achieved Clinical Pregnancy( presence of intrauterine gestational sac detected by transvaginal ultrasound )in a transfer cycle

Time frame: 5 weeks after embryo transfer

Secondary Outcomes

The Number of Participants Who Achieved Ongoing Pregnancy in a Transfer Cycle .

The number of participants who Achieved Ongoing pregnancy (pregnancy for more than 18 weeks after embryo transfer) in a transfer cycle .

Time frame: 18 weeks after embryo transfer

Data from ClinicalTrials.gov

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