A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation

Inclusion Criteria: * Males and females between 18 and 65 years of age, inclusive * Healthy subjects and subjects with documented OIC on stable opioid regimen * Willingness to stop all laxatives throughout the OIC screening and treatment period Exclusion Criteria: * Any clinically significant finding in healthy subjects * Have participated in another clinical trial of an investigational drug 30 days prior to screening * History of chronic constipation prior to opioid therapy in OIC subjects * Active medical disorders associated with diarrhea or intermittent loose stools in OIC subjects